You Do Need power plug adapter while traveling from Guatemala to São Tomé and Príncipe.

Here is Why You Need An Adapter

The outlet and plug type used in São Tomé and Príncipe are C and F and in Guatemala are A and B. This is how they look like.

Guatemala

In Guatemala, outlets of type A and B are in use.

Type A

Type B

São Tomé and Príncipe

In São Tomé and Príncipe, outlets of type C and F are in use.

Type C

Type F