You Do Need power plug adapter while traveling from São Tomé and Príncipe to Vatican City.

Here is Why You Need An Adapter

The outlet and plug type used in Vatican City are C, F and L and in São Tomé and Príncipe are C and F. This is how they look like.

São Tomé and Príncipe

In São Tomé and Príncipe, outlets of type C and F are in use.

Type C

Type F

Vatican City

In Vatican City, outlets of type C, F and L are in use.

Type C

Type F

Type L